Investigative

Cell Biology

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VecStem

The VecStem Endothelial Cell Culture Media from Creative Scientist, Inc. is specially formulated and optimized for robust endothelial cell growth. The complete VecStem media contains 2% human serum, recombinant growth factors, and vitamins. 

 

CORE TECHNOLOGY

Endothelial Colony Forming Cells
 

CELL BASED TOXICOLOGY

Donor-Derived Progenitor Cells for Population-Wide Toxicity Testing

Environmental toxicants affect people differently. A substance harmless to one person can be toxic to another because of genetics, or previous experiences, or both. To identify such vulnerable people we are developing special assay platform utilizing donor-derived progenitor cells.

RADIATION EXPOSURE

We develop an assay platform utilizing donor-specific endothelial progenitor cells as a proxy to test individual sensitivity to ionizing radiation (IR). IR is known to cause long-term complications. In our method, individual IR sensitivity is correlated to an in vitro response to radiation of endothelial progenitor cells, also called endothelial colony forming cells (ECFCs), which critically contribute to the healing of injured tissues. ECFC recruitment, proliferation, and differentiation have been proposed to be a key to tissue recovery after radiation-induced damage. Our assay platform will help to test individual susceptibility to radiation-mediated damage and enable the discovery of novel radioprotectors.

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