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Population-wide assessment of human health is challenging because of intrinsic genetic diversity complicated by age and other non-genetic factors, such as exposure to environmental stressors.
To assess human responses to drugs and toxicants, we develop functional in vitro cell-based assays using highly proliferative primary human cells non-invasively isolated from human tissues.
To study the diversity of responses to drugs and toxicants we compile libraries of Highly Proliferative Primary Cells by growing them in culture and cryopreserving for many years, thus enabling to conduct hundreds of assays from a single donor.
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